Sensitization to apomorphine in pigeons
نویسندگان
چکیده
منابع مشابه
Behavioral Sensitization to Apomorphine in Pigeons
Repeated administration of apomorphine leads to a context-dependent pecking response sens iti zation . Previously sens itized pigeons (Co /llmba /ivia) challenged with saline in the same context show a conditioned response (CR) . The authors studied the effects of intra striatal inj ections of the dopamine (D, ) antagonist SCH-23390 on both the sensiti zed response and the C R. When coadministc...
متن کاملSensitization to apomorphine in pigeons: a multifactorial conditioning process.
Apomorphine (apo), an unspecific direct dopamine agonist, elicits an intense and lasting pecking bout in pigeons. Apo yielded orderly dose-response functions, and repeated administrations led to sensitization. Strain and individual differences in sensitivity to apo were at least partly due to genetic factors. However, a strong cage-context dependency of the sensitization, which is indicative of...
متن کاملSensitization to apomorphine in pigeons is due to conditioning, subject to generalization but resistant to extinction.
Apomorphine (Apo) administration induces a persistent bout of pecking in pigeons and other birds. Repeated injections of Apo in pigeons lead to sensitization, i.e. the pecking response to a particular dose increases up to a dose-dependent asymptotic level. It is also known that Apo-induced pecking can be classically conditioned to the cage environment where the animals experience the effect of ...
متن کاملLong-term behavioral sensitization to apomorphine is independent of conditioning and increases conditioned pecking, but not preference, in pigeons.
When rodents are given a free choice between a variable option and a constant option, they may prefer variability. This preference is even sometimes increased following repeated administration of a dopamine agonist. The present study was the first to examine preference for variability under the systemic administration of a dopamine agonist, apomorphine (Apo), in birds. Experiment 1 tested the d...
متن کاملSensitization to apomorphine, effects of dizocilpine NMDA receptor blockades.
The dopamine agonist apomorphine (apo) elicits bouts of stereotyped pecking in pigeons, a response which increases with successive apo injections. This sensitization is strongly context-specific and has been suggested to arise through a Pavlovian conditioning to both external and internal cues. We hypothetized that this learning involves dopamino-glutamatergic interactions and investigated the ...
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ژورنال
عنوان ژورنال: Behavioural Pharmacology
سال: 2015
ISSN: 0955-8810
DOI: 10.1097/fbp.0000000000000087